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--- sk:studie [2017/05/28 13:09]
pistus [IV.E. Základný výskum na bunkách a nebunkových systémoch]
+++ sk:studie [2017/07/25 17:39]
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-====== Vedecké štúdie a homeopatia ======
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-Vedecké štúdie venujúce sa homeopatií sme rozdelili do štyroch častí:
-  * **I. Databázy a zoznamy štúdií** -  v tejto časti sú odkazy na databázy a zoznamy homeopatických štúdií.
-  * **II. Klinické štúdie klasickej homeopatie** - časť venujúca sa výskumu klasickej (individualizovanej) homeopatie. V metodike týchto štúdii sú dodržané základné princípy homeopatie ako sú zákon podobnosti, podávanie minimálnej dávky a jedného lieku u každého pacienta (bližšie [[http://legatum.sk/sk:homeopathy]]). Predpis lieku je prísne individuálny. Autori stránky považujú výsledky práve týchto štúdií za najrelevantnejšie z pohľadu posúdenia účinnosti/neúčinnosti homeopatie.
-  * **III. Ostatné klinické štúdie s použitím homeopatických liekov** - v tejto časti sú zahrnuté klinické štúdie použitia homeopatických liekov spôsobmi, ktoré nespĺňajú základné princípy homeopatie (bližšie [[http://legatum.sk/sk:homeopathy]]). Predpis homeopatických liekov nie je výlučne individualizovaný. Z výsledkov týchto štúdii preto nie je možné urobiť záver o účinnosti/ neúčinnosti homeopatie.  Väčšina mediálne diskusovaných štúdií homeopatie patrí práve do tejto oblasti.
-  * **IV. Základný výskum v homeopatii** - v tejto časti sme zaradili štúdie predklinického - základného výskumu homeopatie. Cieľom týchto štúdií je bližšie popísať a objasniť fenomény vznikajúce pri použití homeopatík (potencovaných látok) na živé a neživé systémy. Používajú sa tu rôzne fyzikálno-chemické, rastlinné a zvieracie modely.
-===== I. Databázy a zoznamy štúdií =====
-<WRAP round info 60%>
-V tejto časti sú odkazy na databázy a zoznamy homeopatických štúdií.
-</WRAP>
-__I.1.Databázy štúdií:__
-  * **CORE-Hom Database**  - //obsahuje vyše 1100 publikovaných štúdií u ľudí, štúdie sa dajú triediť podľa kritérii, stále dopĺňaná prehľadná databáza// - [[http://archiv.carstens-stiftung.de/core-hom/login.php]]
-  * **CAM-QUEST Database**  - //obsahuje vyše 700 publikovaných štúdií u ľudí, obsahuje nielen homeopatické štúdie// - [[http://www.cam-quest.org/en/search/therapies/?l1=403]]
-  * **HomVetCR Database** - Veterinary Clinical Research-Database in Homeopathy - //obsahuje okolo 300 publikovaných štúdií na zvieratách// - [[http://archiv.carstens-stiftung.de/clinresvet/index.php]]
-  * **HomBRex database** - The Homeopathic Basic Research experiments database - //obsahuje viac než 1700 publikovaných experimentov základneho výskumu, 1300 článkov// - [[http://archiv.carstens-stiftung.de/hombrex/index.php]]
-__I.2.Zoznamy randomizovaných štúdií:__
-  * **Mathie RT (2015) - prehľad štúdii** -- "Controlled clinical studies of homeopathy." Homeopathy. 2015 Oct;104(4):328-32.([[http://www.ncbi.nlm.nih.gov/pubmed/26678738]])
-  * **Mathie RT et al. (2014) - štúdie 2012-2013** --// 27 štúdií//-- "Randomised placebo-controlled trials of individualised homeopathic treatment: systematic review and meta-analysis." Syst Rev. 2014 Dec 6;3:142- Additional File 2.([[http://www.systematicreviewsjournal.com/content/3/1/142]])
-  * **Mathie RT et al. (2013) - štúdie do roku 2011** --// 263 štúdií, porovnanie s dvoma predchádzajúcimi prehľadmi (Linde et al., 1997; Shang et al., 2005)//-- "Randomised controlled trials of homeopathy in humans: characterising the research journal literature for systematic review." Homeopathy. 2013 Jan;102(1):3-24.([[http://www.ncbi.nlm.nih.gov/pubmed/23290875]])
-  * **Clausen J et al. (2013)** -- //prehľad klinických, placebom-kontrolovaných štúdií veterinárnej homeopatie, do apr/2012, 203 kontrolovaných, 146 randomizovaných, 57 nerandomizovaných, 97 placebom-kontrolovaných štúdií// -- "Veterinary Clinical Research Database for Homeopathy: Placebo-controlled trials." Complement Ther Med. 2013 Apr;21(2):115-20. ([[http://www.ncbi.nlm.nih.gov/pubmed/23497815]])
-  * **Mathie et al. (2012)** --//zoznam randomizovaných štúdií v homeopatií u zvierat, do marca 2011, 38 štúdií//-- "Randomised controlled trials of veterinary homeopathy: characterising the peer-reviewed research literature for systematic review". Homeopathy. 2012 Oct;101(4):196-203. ([[http://www.ncbi.nlm.nih.gov/pubmed/23089214]])
-  * **Endler et al. (2010)** - //prehľadová práca, opakované experimenty základného výskumu, 107 štúdií, 24 modelov// - "Repetitions of fundamental research models for homeopathically prepared dilutions beyond 10(-23): a bibliometric study." Homeopathy. 2010 Jan;99(1):25-36.([[http://www.ncbi.nlm.nih.gov/pubmed/20129174]])
-=====II. Klinické štúdie klasickej (individualizovanej) homeopatie=====
-<WRAP round info 60%>
-Časť venujúca sa výskumu klasickej (individualizovanej) homeopatie. V metodike týchto štúdii sú dodržané základné princípy homeopatie ako sú zákon podobnosti, podávanie minimálnej dávky a jedného lieku u každého pacienta (bližšie [[http://legatum.sk/sk:homeopathy]]). Predpis lieku je prísne individuálny. Autori stránky považujú výsledky práve týchto štúdií za najrelevantnejšie z pohľadu posúdenia účinnosti/neúčinnosti homeopatie.
-</WRAP>
-__ II.1.) Metaanalýzy __
-  * **Mathie RT et al. (2014)** - do roku 2014 najväčšia analýza randomizovaných štúdií individualizovanej homeopatie (peer-reviewed). __Záver:__ možný špecifický účinok homeopatie (POR 1,53-1,98; p<0,001); __celkovo nižšia kvalita__ sledovaných štúdii; nepotvrdilo sa, že štúdie s nižšou kvalitou vykazujú väčší terapeutický účinok homeopatie oproti štúdiám vyššej kvality; potreba ďalších štúdií "Randomised placebo-controlled trials of individualised homeopathic treatment: systematic review and meta-analysis." Syst Rev. 2014 Dec 6;3:142.([[http://www.systematicreviewsjournal.com/content/3/1/142]])
-  * **Nuhn et al. (2010)** - --//Vplyv placeba u randomizovaných placebom kontrolovaných štúdií v klasickej homeopatií nezdá sa byť väčší ako u konvenčných štúdií.//-- "Placebo effect sizes in homeopathic compared to conventional drugs - a systematic review of randomised controlled trials." Homeopathy. 2010 Jan;99(1):76-82. ([[http://www.ncbi.nlm.nih.gov/pubmed/20129180]])
-  * **Linde K, Melchart D (1998)** -  __Záver:__ možný špecifický účinok homeopatie; celkovo nižšia kvalita sledovaných štúdii; potreba ďalších štúdií "Randomized controlled trials of individualized homeopathy: a state-of-the-art review." J Altern Complement Med. 1998 Winter;4(4):371-88.([[http://www.ncbi.nlm.nih.gov/pubmed/9884175]], [[http://homeopathie-wijtenburg.nl/wp-content/uploads/2014/10/5-Linde-review-individualized-hom-JACM-1998.pdf]])
-  * **Ernst, (1998)** - --//komparatívna štúdia-vybraných 6 homeopatických a alopatických štúdií, __nedostatočne popísaná metodika výberu štúdií a hodnotenia ich kvality__ so __záverom:__ Slabá kvalita štúdii. Homeopatia v 2 štúdiách účinnejšia, v 2 horšia a v 2 rovnako účinná ako alopatická liečba. Nie je možné urobiť záver. // [[http://www.crd.york.ac.uk/crdweb/ShowRecord.asp?View=Full&ID=11999000356#.VVEFdNPtlBd]]
-=====III. Ostatné klinické štúdie s použitím homeopatických liekov=====
-<WRAP round info 60%>
-V tejto časti sú zahrnuté klinické štúdie použitia homeopatických liekov spôsobmi, ktoré nespĺňajú základné princípy homeopatie (bližšie [[http://legatum.sk/sk:homeopathy]]). Predpis homeopatických liekov nie je výlučne individualizovaný. __Z výsledkov týchto štúdii preto nie je možné urobiť záver o účinnosti/ neúčinnosti homeopatie.  Väčšina mediálne diskusovaných štúdií homeopatie patrí práve do tejto oblasti__. Bližšie Vithoulkas,2017 ([[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304371/]])
-</WRAP>
-==== III.A. Ostatné klinické štúdie u ľudí ====
-__ III.A.1.) Metaanalýza účinnosti homeopatie bez individualizovanej (klasickej) homeopatie __
-  * **Mathie et al (2017)** -- Záver: analýza 75 randomizovaných štúdii (pre 48 klinických stavov do konca roku 2014) neindividualizovanej homeopatie ukazuje signifikantný rozdiel účinnosti homeopatie oproti placebu. Avšak pri zhodnotení kvalitnejších štúdii nebol prítomný signifikantný rozdiel v efektivite oproti placebu. "Randomised, double-blind, placebo-controlled trials of non-individualised homeopathic treatment: systematic review and meta-analysis." ([[https://www.ncbi.nlm.nih.gov/pubmed/28340607]])
-__ III.A.2.) Globálne metaanalýzy homeopatie - novšie __
-<WRAP round info 60%>
-// Jedná sa o metaanalýzy klinických homeopatických štúdii ako celku. Neberie sa ohľad na rozdiely medzi jednotlivými formami homeopatie (individualizovaná homeopatia, použitie polykomponentných prípravkov, homeopatia podľa štandardných diagnóz, izopatia, atď.) a ani sa v nich neposudzuje správnosť použitej homeopatie v jednotlilvých štúdiách. Výrazne to znižuje hodnotu a možnosť generalizovania záverov týchto metaanalýz.// </WRAP>
-  * **Stub et al (2016)** -- "Adverse effects of homeopathy, what do we know? A systematic review and meta-analysis of randomized controlled trials." //Klinické zhoršenie pacientov (tzv.homeopatické zhoršenie) je bežne popisované v homeopatických štúdiách. Percento klinicky zhoršených pacientov pri homeopatickej liečbe sa nelíši od klinicky zhoršených pacientov pri placebe a konvenčnej liečbe. Prehľadová práca a metanalýza randomizovaných klinických štúdii 1995-2011.//  ([[https://www.ncbi.nlm.nih.gov/pubmed/27261996]])
-  * **Australian NHMRC statement (2015)** ([[https://www.nhmrc.gov.au/health-topics/complementary-medicines/homeopathy-review]])- __//Kritický komentár://__ [[https://www.hri-research.org/resources/homeopathy-the-debate/the-australian-report-on-homeopathy/australian-nhmrc-report-in-detail/]], [[http://www.homeopathyoz.org/news-8.html]]
-  * **Bornhöft G. et al. (2011)** -- "Homeopathy in Healthcare – Effectiveness, Appropriateness, Safety, Costs - An HTA report on homeopathy as part of the Swiss Complementary Medicine Evaluation Programme."([[http://link.springer.com/book/10.1007/978-3-642-20638-2/page/1]])
-  * **Bornhöft G. et al. (2006)** -- "Effectiveness, safety and cost-effectiveness of homeopathy in general practice - summarized health technology assessment." Forsch Komplementmed. 2006;13 Suppl 2:19-29. Epub 2006 Jun 26. - [[http://www.ncbi.nlm.nih.gov/pubmed/16883077|http://www.ncbi.nlm.nih.gov/pubmed/16883077]]. __//Komentáre k práci Bornhöfta a kol.://__ //Shaw DM. The Swiss report on homeopathy: a case study of research misconduct. Swiss Med Wkly. 2012 May 31;142:w13594. [[http://www.smw.ch/content/smw-2012-13594/]] // //Reply to Shaw DM: von Ammon K, Bornhöft G, Maxion-Bergemann S, Righetti M, Baumgartner S,Thurneysen A, Wolf U, Matthiessen PF. Familiarity, objectivity - and misconduct: Counterstatement to Shaw DM. The Swiss Report on homoeopathy: a case study of research misconduct. Swiss Med Wkly. 2012;142:w13594. [[http://www.smw.ch/content/smw-2013-13720/]] //
-  * **Shang A et al. (2005)** -- "Are the clinical effects of homoeopathy placebo effects? Comparative study of placebo-controlled trials of homoeopathy and allopathy". Lancet. 2005 Aug 27-Sep 2;366(9487):726-32. [[http://www.ncbi.nlm.nih.gov/pubmed/16125589]]. __Popis štúdie:__//- Na analýzu bolo vybraných 110 homeopatických štúdií a 110 zodpovedajúcich štúdií konvenčnej medicíny. Konečné závery vznikli porovnaním štúdií väčších s lepšou kvalitou (1.pilier výskumu homeopatie-viď úvod) – 8 homeopatických a 6 konvenčnej medicíny. __Záver Shang et al.__:  Dôkaz špecifického pôsobenia homeopatie je slabý, kdežto existuje silný dôkaz špecifického pôsobenia konvenčnej medicíny. __Komentáre k práci Shanga et al.:__ Aj v tejto práci sa neprihliada ku kvalite použitej homeopatie (viď úvod) - iba dve z 8 porovnávaných homeopatických štúdií ([[https://apgaylard.wordpress.com/2007/11/28/the-myth-of-the-secret-eight/]]) mali dostatočnú kvalitu a skúmali individualizovanú (klasickú) homeopatiu (konkrétne Walach et al. 1997, Jacobs et al. 2000). To je dôvod nízkej externej validity výsledkov.//
-__ III.A.3.) Globálne metaanalýzy homeopatie - staršie __
-  * **a.) s dôležitými námietkami, ale homeopatia sa skôr líši od placeba:**
-        * Jonas et al, 2003 - [[http://www.annals.org/content/138/5/393.long]]
-        * Cucherat et al, 2000 - [[http://www.ncbi.nlm.nih.gov/pubmed/10853874]]
-        * Linde et al, 1997 - [[http://www.ncbi.nlm.nih.gov/pubmed/9310601]] - //nadstavba štúdie:// - Linde et al, 1999 - [[http://www.ncbi.nlm.nih.gov/pubmed/10391656]] - komentované: Ernst et al, 2000 - [[http://www.ncbi.nlm.nih.gov/pubmed/11186614]] a Ludtke,2002 - [[http://www.ncbi.nlm.nih.gov/pubmed/11781130]]
-        * Kleijnen et al, 1991 - [[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1668980/]]
-  * **b.) homeopatia sa nelíši od placeba**
-        * Ernst et al, 2002 - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874503/
-  * **c.) nezatriedené**
-        *Linde et al, 2001 - [[http://www.biomedcentral.com/1472-6882/1/4]]
-__ III.A.4.) Vybrané užšie metaanalýzy (špecifické medicínske diagnózy, homeopatiká)__
-  * **Banerjee et al. (2017)**. "Homeopathy for Allergic Rhinitis: A Systematic Review." -- Homeopatické randomizované štúdie pri alergickej rinitíde - nájdených celkovo 11 štúdií do decembra 2015 (izopatia, Galphimia glauca, nosný sprej). Záver: použitie Galphinie a homeopatického nosného spreja môže mať benefit na nosné a očné príznaky. Slabá kvalita štúdií. Doteraz neexistuje štúdia individualizovanej homeopatie u alergickej rinitídy. ([[https://www.ncbi.nlm.nih.gov/pubmed/28437146]])
-  * **Mathie RT, Frye J, Fisher P (2015)**. Homeopathic Oscillococcinum® for preventing and treating influenza and influenza-like illness. Cochrane Database Syst Rev. 2015 Jan 28;1:CD001957. ([[http://www.ncbi.nlm.nih.gov/pubmed/25629583]])
-==== III.B. Ostatné klinické štúdie u zvierat ====
-__ III.B.1.)  Metaanalýzy __
-  * **Mathie, Clausen (2015)** --//prvá globálna metaanalýza klinických randomizovaných štúdii veterinárnej homeopatie; zahŕňa 2 štúdie individualizovanej homeopatie, 10 štúdií neindividualizovanej homeopatie, 6 profylaktických štúdií// - __Záver:__ nízka kvalita štúdií, možný efekt homeopatickej liečby (OR=1,69-2,62, p=0,01-0,02). "Veterinary homeopathy: meta-analysis of randomised placebo-controlled trials." Homeopathy. 2015 Jan;104(1):3-8. [[http://www.ncbi.nlm.nih.gov/pubmed/25576265]]; Vet.Rec (2014) - [[http://www.ncbi.nlm.nih.gov/pubmed/25324413]]
-__ III.B.2.)   Vybrané klinické štúdie u zvierat __
-  * **Camerlink I. et al.(2010)** "Homeopathy as replacement to antibiotics in the case of Escherichia coli diarrhoea in neonatal piglets." Homeopathy. 2010 Jan;99(1):57-62. - [[http://www.ncbi.nlm.nih.gov/pubmed/20129177|http://www.ncbi.nlm.nih.gov/pubmed/20129177]]
-=====IV. Základný výskum v homeopatii=====
-<WRAP round info 60%>
-V tejto časti sme zaradili štúdie základného výskumu. Cieľom týchto štúdií je bližšie popísať a objasniť fenomény vznikajúce pri použití homeopatík (potencovaných látok) na živé a neživé systémy. Používajú sa tu rôzne fyzikálno-chemické, rastlinné, zvieracie a ľudské modely.
-</WRAP>
-==== IV.A. Základný výskum na ľuďoch ====
-//predpoklady vybratých štúdií: použitie vysokých potencií (12CH a viac) a zaslepené skúšanie//
-__ IV.A.1.) ovplyvnenie chorôb u ľudí:__
-  * **Teixeira MZ et al. ** -- //použitie potencovaného estrogénu pri zmiernení príznakov endometriózy. Príznaky endometriózy sú viazané na vyššie hladiny estrogénu. n=50 žien// -- "Potentized estrogen in homeopathic treatment of endometriosis-associated pelvic pain: A 24-week, randomized, double-blind, placebo-controlled study.". Eur J Obstet Gynecol Reprod Biol. 2017 Jan 25;211:48-55. ([[https://www.ncbi.nlm.nih.gov/pubmed/28187404]])
-==== IV.B. Základný výskum na zvieratách ====
-//predpoklady vybratých štúdií: použitie vysokých potencií (12CH a viac) a zaslepené skúšanie//
-__ IV.B.1.) Ovplyvnenie fyziologických funkcií zvierat: __
-  * **Endler et al. (2007)** "Treatment of lowland frogs from the spawn stage with homeopathically prepared thyroxin (10(-30))." ScientificWorldJournal. 2007 Oct 22;7:1697-702. - [[http://www.ncbi.nlm.nih.gov/pubmed/17982565|http://www.ncbi.nlm.nih.gov/pubmed/17982565]]
-  * **Ruiz-Vega et al. (2005) **-- "Histamine at high dilution reduces spectral density in delta band in sleeping rats". Homeopathy (2005), Vol. 94(2), pp. 86-91 ([[http://www.ncbi.nlm.nih.gov/pubmed/15892488]])
-  * **Welles et al. (2007) **-- "Pretreatment with thyroxin 10(-8) and the effect of homeopathically prepared thyroxin 10(-30) on highland frogs--a multi-researcher study." Forsch Komplementärmed (2007), Vol. 14(6), pp. 353-357 ([[http://www.ncbi.nlm.nih.gov/pubmed/18219210]])
-  * **Weber et al. (2008) **-- "The effect of homeopathically prepared thyroxine on highland frogs: influence of electromagnetic fields". Homeopathy (2008), Vol. 97(1), pp. 3-9 ([[http://www.ncbi.nlm.nih.gov/pubmed/18194759]])
-  * **de Oliviera et al. (2011) **--"Mercurius solubilis: actions on macrophages". Homeopathy (2011), Vol. 100(4), pp. 228-236 ([[http://www.ncbi.nlm.nih.gov/pubmed/21962197]])
-  * **Kiefer et al. (2012) ** --"Lowland amphibians - recalculation of data on effects of diluted thyroxine". Int J High Dil Res (2012), Vol. 11(38), pp. 3-18 ([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/view/526]])
-//negatívny výsledok://
-  * **Velkers et al. (2005) **-- "Isopathic and pluralist homeopathic treatment of commercial broilers with experimentally induced colibacillosis" Res Vet Science (2005), Vol. 78(1), pp. 77-83([[http://www.ncbi.nlm.nih.gov/pubmed/15500843]])
-  * **Siegling-Vlitakis et al. (2009) **-- "In vitro examination of potentized atropine sulfate dilutions on the contractility of the isolated rat ileum". J Altern Complement Med (2009), Vol. 15(10), pp. 1121-1126([[http://www.ncbi.nlm.nih.gov/pubmed/19824820]])
-__ IV.B.2.) ovplyvnenie chorôb a toxikologické štúdie u zvierat (okrem klinických štúdií s individualizovanou homeopatiou):__
-  * **Clausen J et al. ** -- //prehľadová práca, 48 štúdií z rokov 1832-2009// -- "Infection models in basic research on homeopathy". Homeopathy. 2010 Oct;99(4):263-70. ([[http://www.ncbi.nlm.nih.gov/pubmed/20970096]])
-//novšie alebo vybrané staršie štúdie://
-  * **Biswas et al. (2005) **--"Efficacy of the potentized homeopathic drug, Carcinosin 200, fed alone and in combination with another drug, Chelidonium 200, in amelioration of p-Dimethylaminoazobenzene-induced hepatocarcinogenesis in mice". J Altern Complement Med (2005), Vol. 11(5), pp. 839-854 ([[http://www.ncbi.nlm.nih.gov/pubmed/16296917]])
-  * **Paula Coelho et al. (2006) **-- "Therapeutic and pathogenetic animal models for Dolichos pruriens". Homeopathy (2006), Vol. 95(3), pp. 136-143([[http://www.ncbi.nlm.nih.gov/pubmed/16815516]])
-  * **Jonas et al. (2006) **-- "Can homeopathic treatment slow prostate cancer growth?" Integr Cancer Ther (2006), Vol. 5(4), pp. 343-349 ([[http://www.ncbi.nlm.nih.gov/pubmed/17101763]])
-  * **MacLaughlin et al. (2006) **-- "Effects of homeopathic preparations on human prostate cancer growth in cellular and animal models". Integr Cancer Ther (2006), Vol. 5(4), pp. 362-372 ([[http://www.ncbi.nlm.nih.gov/pubmed/17101766]])
-  * **Banerjee et al. (2007) **-- "A potentized homeopathic drug, Arsenicum album 200, can ameliorate genotoxicity induced by repeated injections of arsenic trioxide in mice". J Vet Med (A) (2007), Vol. 54(7), pp. 370-376([[http://www.ncbi.nlm.nih.gov/pubmed/17718811]])
-  * **Pathak et al. (2007) **-- "Supportive evidence for the anticancerous potential of alternative medicine against hepatocarcinogenesis in mice". Forsch Komplementärmed (2007), Vol. 14(3), pp. 148-156 ([[http://www.ncbi.nlm.nih.gov/pubmed/17596695]])
-  * **Bhattacharjee et al. (2009) **-- "Homeopathic drugs Natrum sulphuricum and Carcinosin prevent azo dye-induced hepatocarcinogenesis in mice". Indian J Biochem Biophys (2009), Vol. 46(4), pp. 307-318 ([[http://www.ncbi.nlm.nih.gov/pubmed/19788063]])
-  * **Bhattacharjee et al. (2009) **-- "Amelioration of carcinogen-induced toxicity in mice by administration of a potentized homeopathic drug, Natrum sulphuricum 200". eCAM (2009), Vol. 6(1), pp. 65-75 ([[http://www.hindawi.com/journals/ecam/2009/521217/abs/]])
-  * **Goncalves de Araujo et al. (2009) **-- "Effect of Mercurius solubilis on the bacteriological response in the alveolitis process in rats". Homeopathy (2009), Vol. 98(3), pp. 160-164 ([[http://www.ncbi.nlm.nih.gov/pubmed/19647210]])
-  * **Kuzeff et al. (2009) **-- "Isopathic versus enantiomeric inhibition of U-50488 HCl toxicity" Homeopathy (2009), Vol. 98(2), pp. 83-87 ([[http://www.ncbi.nlm.nih.gov/pubmed/19358960]])
-  * **Pathak et al. (2009) **-- "Combinational homeopathic therapy reduces genotoxicity and cytotoxicity in mice fed carcinogenesis". Clin Exp Hom (2009), Vol. 1(1), pp. (1-10) ([[http://www.sukulhomeopathy.com/newjournal/khuda-buksh1.pdf]])
-  * **Viriato et al. (2009) **-- "Study of high dilution of copaiba oil on inflammatory process". Int J High Dil Res (2009), Vol. 8(26), pp. 9-14 ([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewFile/305/380]])
-  * **Banerjee et al. (2010) **-- "Chelidonium majus 30C and 200C in induced hepato-toxicity in rats". Homeopathy (2010), Vol. 99(3)([[http://www.ncbi.nlm.nih.gov/pubmed/20674840]])
-  * **Ghilosso-Bortolini et al. (2010) **-- "Putative protective effect of Cadmium chloride high diluted solution on LLC-PK1 cell intoxicated by high concentration of this same metal". Int J High Dil Res (2010), Vol. 9(30), pp. 16-29 ([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewArticle/381]])
-  * **Magnani et al. (2010) ** --"Dose-effect study of Gelsemium sempervirens in high dilutions on anxiety-related responses in mice". Psychopharmacology (2010), Vol. 210(4), pp. 533-545 ([[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877813/]])
-  * **Banerjee et al. (2011) **-- "Evidences of protective potentials of microdoses of ultra-high diluted arsenic trioxide in mice receiving repeated injections of arsenic trioxide". eCAM (2011), Vol. 2011 ([[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135423/]])
-  * **Patil et al. (2011) **-- "Modulation of arthritis in rats by Toxicodendron pubescens and its homeopathic dilutions". Homeopathy (2011), Vol. 100(3) ([[http://www.ncbi.nlm.nih.gov/pubmed/21784329]])
-  * **Bellavite et al. (2011) **-- "Effects of high-dilutions in behavioural models: a commentary on critical issues, from reproducibility to plausibility". Int J High Dilution Res 2011; 10(37): 325-337 ([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewFile/532/550]])
-  * **Bhattacharjee, Khuda-Bukhsh (2012) **-- "Two homeopathic remedies used intermittently provide additional protective effects against hepatotoxicity induced by carcinogens in mice" J Acupunct Meridian Stud (2012), Vol. 5(4), pp. 166-175 (http://www.ncbi.nlm.nih.gov/pubmed/22898065)
-  * **Mohammadi et al. (2012) **-- "Homeopathic treatment for peripheral nerve regeneration: an experimental study in a rat sciatic nerve transection model." Homeopathy (2012), Vol. 101(3), pp. 141-146 ([[http://www.ncbi.nlm.nih.gov/pubmed/22818230]])
-  * **Patel et al. (2012) **-- "Toxicodendron pubescens retains its anti-arthritic efficacy at 1M, 10M and CM homeopathic dilutions." Homeopathy (2012), Vol. 101(3), pp. 165-170 ([[http://www.ncbi.nlm.nih.gov/pubmed/22818234]])
-  * **Bellavite et al. (2012) **--"Testing homeopathy in mouse emotional response models: pooled data analysis of two series of studies". eCAM (2012), Vol. Article ID 954374, pp. 1-9 ([[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324905/]])
-  * **Heine et al. (2012) ** --"Assessment of homeopathic medicine Aconitum napellus in the treatment of anxiety in an animal model". Int J High Dilution Res 2012; 11(38):33-42 ([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewArticle/547]])
-//negatívny výsledok://
-  * **Almeida et al. (2009) ** -- "Homeopathic treatment for bone regeneration: experimental study." Homeopathy (2009), Apr;98(2):92-6. ([[http://www.ncbi.nlm.nih.gov/pubmed/19358962]])
-==== IV.C. Základný výskum na rastlinách (do roku 2014) ====
-__ IV.C.1.) ovplyvnenie fyziologických funkcií rastlín (rastu, zloženia,...):__
-  * **Majewsky et al. (2009) **- //prehľadová práca štúdií z rokov 1920-2009, 86 štúdií// -  "Use of homeopathic preparations in experimental studies with healthy plants." Homeopathy. 2009 Oct;98(4):228-43.([[http://www.ncbi.nlm.nih.gov/pubmed/19945677]])
-//novšie alebo vybrané staršie štúdie://
-* __ IV.C.1.a) Ovplyvnenie rastu __
-* __ - potencované látky - viaceré __
-  * **Jäger et al. (2010) ** - (prednáška) "Comparative study of two bioassays with weakened duckweed and yeast treated with homeopathic preparations" Int J High Dilution Res 2012; 11(40):129-130 ([[http://www.researchgate.net/publication/257874737_P01.52._Comparative_study_of_two_bioassays_with_stressed_duckweed_and_yeast_treated_with_homeopathic_preparations]])
-  * **Gangar (2010) ** - "Management of genetic activity through homoeopathy." Int J Pharma Bio Sci (2010), Vol. 1(2), pp. 1-13([[http://www.ijpbs.net/issue-2/177.pdf]])
-  * **Scherr et al. (2009) **  - "Effects of potentised substances on growth rate of the water plant Lemna gibba L." Complement Ther Med. 2009 Apr;17(2):63-70.([[http://www.ncbi.nlm.nih.gov/pubmed/19185263]])
-  * **Scherr C et al. (2007) ** - "Duckweed (Lemna gibba L.) as a test organism for homeopathic potencies." J Altern Complement Med. 2007 Nov;13(9):931-7.([[http://www.ncbi.nlm.nih.gov/pubmed/18047439]])
-  * **Baumgartner et al. (2004) ** - "Growth Stimulation of Dwarf Peas (Pisum sativum L.) Through Homeopathic Potencies of Plant Growth Substances." Forsch Komplementärmed (2004), Vol. 11(5), pp. 281-292([[http://www.ncbi.nlm.nih.gov/pubmed/15572869]])
-* __ - potencované giberelíny __
-  * **Majewsky et al. (2014). **  --"Reproducibility of effects of homeopathically potentised gibberellic acid on the growth of Lemna gibba L. in a randomised and blinded bioassay." Homeopathy. 2014 Apr;103(2):113-26. ([[http://www.ncbi.nlm.nih.gov/pubmed/24685416]])
-  * **Hribar-Marko et al. (2013). **  --"Prestimulation of wheat seedlings with gibberellic acid followed by application of an agitated high dilution of the same hormone" Int J High Dilution Res (2013), Vol. 12(42), pp. 26-39 ([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewArticle/617]])
-  * **Hribar-Marko et al. (2012). **  --"Pre stimulation by gibberellic acid and the effect of extremely diluted agitated gibberellic acid on wheat stalk growth." Int J High Dilution Res 2012; 11: 124e125. ([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewArticle/605]])
-  * **Kiefer ET AL. (2012) ** - "Wheat germination and highly diluted agitated gibberellic acid (10 -30) - a multi researcher study". Int J High Dil Res (2012), Vol. 11(39), pp. 45-59([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/view/428]])
-  * **Endler et al. (2011) ** - "Seasonal Variation of the Effect of Extremely Diluted Agitated Gibberellic Acid (10e-30) on Wheat Stalk Growth: A Multiresearcher Study". TheSWJ Volume 11 (2011), Pages 1667-1678 ([[http://www.hindawi.com/journals/tswj/2011/462736/]])
-  * **Pfleger et al. (2011) **  - "The effect of extremely diluted agitated gibberellic acid (10e-30) on wheat stalk growth-A two researcher pilot study." Complement Ther Med. 2011 Jun;19(3):164-9. Epub 2011 May 20. - [[http://www.ncbi.nlm.nih.gov/pubmed/21641523|http://www.ncbi.nlm.nih.gov/pubmed/21641523]]
-  * **Bonfim et al. (2008) **  - "Use of homeopathic Arnica montana for the issuance of roots of Rosmarinus officinalis L. and Lippia alba (Mill.) N.E.Br." Int J High Dil Res (2008), Vol. 7(23), pp. 72-76([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewArticle/276]])
-* __ IV.C.1.b) Ovplyvnenie chemického zloženia __
-  * **Bonato et al. (2009) ** - "Homeopathic drugs Arsenicum album and Sulphur affect the growth and essential oil content in mint (Mentha arvensis L.)" Acta Scientarum Agronomy (2009), Vol. 31(1), pp. 101-105([[http://periodicos.uem.br/ojs/index.php/ActaSciAgron/article/view/6642]])
-* __ IV.C.1.c) Iné: __
- -
-__ IV.C.2.) ovplyvnenie rastlinných chorôb:__
-  * **Betti et al. (2009) ** - //prehľad fytopatologických štúdii z rokov 1969-2009, 44 štúdií, rastlina + vírusy, huby, baktérie, nematody// - "Use of homeopathic preparations in phytopathological models and in field trials: a critical review." Homeopathy. 2009 Oct;98(4):244-66.([[http://www.ncbi.nlm.nih.gov/pubmed/19945678]])
-//novšie alebo vybrané staršie štúdie://
-  * **Datta, Datta (2012) **- "Homeopathic medicines protect environment, health and development by controlling mulberry disease." J Homeopath Ayurv Med (2012), Vol. 1(1), pp. 1-7([[http://www.omicsgroup.org/journals/2167-1206/2167-1206-1-104.php?aid=4121]])
-  * **Wyss et al. (2010) **- "Homeopathic preparations to control the rosy apple aphid (Dysaphis plantaginea Pass.)" Scientific World J (2010), Vol. 10, pp. 38-48([[http://www.hindawi.com/journals/tswj/2010/358407/abs/]])
-  * **Shah-Rossi et al. (2009) **- "Homeopathic treatment of Arabidopsis thaliana plants infected with Pseudomonas syringae." ScientificWorldJournal. 2009 May 20;9:320-30. ([[http://www.ncbi.nlm.nih.gov/pubmed/19468651]])
-  * **Datta (2006) ** - "Effects of Cina on root-knot disease of mulberry." Homeopathy. 2006 Apr;95(2):98-102.([[http://www.ncbi.nlm.nih.gov/pubmed/16569626]])
-  * **Sukul et al. (2006) ** - "Amelioration of root-knot disease of lady's finger plants by potentized Cina and Santonin." Homeopathy. 2006 Jul;95(3):144-7.([[http://www.ncbi.nlm.nih.gov/pubmed/16815517]])
-__ IV.C.3.) zvýšenie odolnosti rastlín voči vonkajším vplyvom__
-  * **Jäger et al. (2011) ** -- //prehľadová práca štúdií z rokov 1920-2010, 34 štúdií rôznej kvality// - "Use of homeopathic preparations in experimental studies with abiotically stressed plants." Homeopathy. 2011 Oct;100(4):275-87.([[http://www.ncbi.nlm.nih.gov/pubmed/21962204]])
-//novšie alebo vybrané staršie štúdie://
-  * **Betti et al. (2013) ** -- "Extremely low doses of arsenic affect in vitro pollen germination." Forsch Komplementmed. 2013;20(4):254-60. ([[http://www.ncbi.nlm.nih.gov/pubmed/24030446]])
-  * **Jäger et al. (2012) ** -- "Comparative study of two bioassays with weakened duckweed and yeast treated with homeopathic preparations." Int J High Dilution Res 2012; 11: 129e130. ([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/view/574]])
-  * **Mondal et al. (2012) ** --"Natrum mur 200c promotes seed germination and increases total protein, chlorophyll, rubisco and sugar in early seedlings of cowpea under salt stress." Int JHigh Dilution Res 2012; 11: 128. ([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/view/570]])
-  * **Brizzi et al. (2011) ** - "The efficacy of ultramolecular aqueous dilutions on a wheat germination model as a function of heat and aging-time". eCAM (2011), Vol. 2011, pp. 696298; (1-11)([[http://www.hindawi.com/journals/ecam/2011/696298/]])
-  * **Bonfim et al. (2010) ** - " Germination and vigor of lettuce seeds (Lactuca sativa L.) pelleted with homeopathic preparations Alumina and Calcarea carbonica subjected to toxic levels of aluminum". Int J High Dil Res (2010), Vol. 9(33), pp. 138-146 ([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewFile/412/450]])
-  * **Jäger et al. (2010) **- "Effects of homeopathic arsenicum album, nosode, and gibberellic acid preparations on the growth rate of arsenic-impaired duckweed (Lemna gibba L.)" Scientific World J (2010), Vol. 10, pp. 2112-2129([[http://www.hindawi.com/journals/tswj/2010/107597/abs/]])
-  * **Lahnstein et al. (2009) **- "Isopathic treatment effects of Arsenicum album 45x on wheat seedling growth--further reproduction trials." Homeopathy (2009), Vol. 98(4)([[http://www.ncbi.nlm.nih.gov/pubmed/19945675]])
-  * **Binder et al. (2005) **- "The effects of a 45x potency of arsenicum album on wheat seedling growth -- a reproduction trial." Forsch Komplementarmed Klass Naturheilkd. 2005 Oct;12(5):284-91.([[http://www.ncbi.nlm.nih.gov/pubmed/16230858]])
-__ IV.C.4.) ďalšie špecifické výskumné modely__
-  * **Baumgartner et al. (2014) **- "Spatial allocation effects within a potentization basic research model – evidence for field-like effects of homeopathic preparations? " International Journal of High Dilution Research, Vol 13, No 47 (2014).([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewArticle/748]])
-==== IV.D. Základný výskum na baktériách ====
-  * **Saha et al. (2012) ** -- "Phenotypic evidence of ultra-highly diluted homeopathic remedies acting at gene expression level: a novel probe on experimental phage infectivity in bacteria" Journal of Chinese Integrative Medicine (2012), Vol. 10(4), pp. 462-470 ([[http://www.ncbi.nlm.nih.gov/pubmed/22500721]])
-  * **Das S et al. (2012) ** -- "Potential of the homeopathic remedy, Arnica Montana 30C, to reduce DNA damage in Escherichia coli exposed to ultraviolet irradiation through up-regulation of nucleotide excision repair genes. Zhong Xi Yi Jie He Xue Bao. 2012 Mar;10(3):337-46. ([[http://www.ncbi.nlm.nih.gov/pubmed/22409925]])
-  * **De A et al. (2012) **-- "Potentized homeopathic drug Arsenicum album 30C inhibits intracellular reactive oxygen species generation and up-regulates expression of arsenic resistance gene in arsenine-exposed bacteria Escherichia coli" J Chin Integr Med (2012), Vol. 10(2), pp. 210-227 ([[http://www.jcimjournal.com/en/FullText2.aspx?articleID=jcim20120212]])
-==== IV.E. Základný výskum na bunkách a nebunkových systémoch ====
-  * **Witt et al., (2007) ** - sytematický prehľad, 67 experimentov z rokov 1966-2005, 1/3 replikovaný výskum- zahrnuté nebunkové systémy(väčšinou enzýmy), bunkové kultúry, bunky izolované z organizmov (erytrocyty, bazofily, neutrofily, lymfocyty) [[http://www.ncbi.nlm.nih.gov/pubmed/17544864]]
-//novšie alebo vybrané staršie štúdie://
-  * **Malarczyk, E. (2008) ** - "Kinetic changes in activity of HR-peroxidase, induced by very low doses of phenol". Int J High Dil Res (2008), Vol. 7(23), pp. 3-11 ([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewFile/37/349]])
-//efekt na zmenu expresie génov buniek://
-  * **Olsen, S. (2017) ** - "Effects of ultra-high dilutions of sodium butyrate on viability and gene expression in HEK 293 cells.". Homeopathy 2017 Feb;106(1):32-36 ([[https://www.ncbi.nlm.nih.gov/pubmed/28325222]]) - diskusia s ďalšími staršími štúdiami.
-==== IV.F. Fyzikálno-chemické laboratórne modely ====
-__ IV.F.1.) Termoluminiscencia__
-  * **Rey L. (2003)** - "Thermoluminescence of ultra-high dilutions of lithium chloride and sodium chloride." Physica A (2003), Vol. 323, pp. 67-74. ([[http://dx.doi.org/10.1016/S0378-4371(03)00047-5]])
-  * **van Wijk R et al. (2006) ** - "Thermoluminescence in ultra-high dilution research." J Altern Complement Med. 2006 Jun;12(5):437-43.([[http://www.ncbi.nlm.nih.gov/pubmed/16813507]])
-  * **Rey L. (2007) ** - "Can low-temperature thermoluminescence cast light on the nature of ultra-high dilutions?" Homeopathy (2007), Vol. 96(3), pp. 170-174. ([[http://www.ncbi.nlm.nih.gov/pubmed/17678813]])
-__ IV.F.2.) Spektroskopia__
-  * **Klein SD., Wolf U. (2016). **  --"Comparison of homeopathic globules prepared from high and ultra-high dilutions of various starting materials by ultraviolet light spectroscopy" / Complementary Therapies in Medicine 24 (2016) 111–117. ([[http://www.complementarytherapiesinmedicine.com/article/S0965-2299%2815%2930038-8/pdf]])
-  * **Sukul et al. (2005) ** - //FTIR// - "Variation in Fourier transform infrared spectra of some homeopathic potencies and their diluent media. J Altern Complement Med. 2005 Oct;11(5):807-12. ([[http://www.ncbi.nlm.nih.gov/pubmed/16296914]])
-  * **Rao et al. (2008) ** - //UV spektroskopia, Ramanova spektroskopia// - "Characterization of the structure of ultra dilute sols with remarkable biological properties" Mater Lett. 2008 April 15; 62(10-11): 1487. ([[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822343/]])
-  * **Bhattacharya et  al. (2008) ** - //rôzne spektroskopie, rozdiely v spektrách pri rôznych nádobách, potenciách, pri rôznych postupoch prípravy, in vitro ovplyvnenie rastu HeLa// - "In vitro studies demonstrate anticancer activity of an alkaloid of the plant Gelsemium sempervirens". Exp Biol Med (2008), Vol. 233(12), pp. 1591-1601. ([[http://www.ncbi.nlm.nih.gov/pubmed/18997108]])
-  * **Botha I, Ross AH. (2008) ** - //MR spektrokopia// - "A nuclear magnetic resonance spectroscopy comparison of 3C trituration derived and 4C trituration derived remedies". Homeopathy. 2008 Oct;97(4):196-201. ([[http://www.ncbi.nlm.nih.gov/pubmed/19371568]])
-  * **de Alvarenga et al. (2009) ** - //13C MR spektroskopia// - "Effect of Magnesium phosphoricum 12c on Sodium Dodecylsulphate by 13C nuclear magnetic resonance". Int J High Dil Res (2009), Vol. 8(26), pp. 3-8 ([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/view/324/379]])
-  * **Sharma A., Purkait B. (2009) **- //UV spektroskopia// - "Energy in Commercially Available Ultra-Diluted Natural Cardiotropic Drug Digitalis purpurea: An UV Spectroscopic Study. Research Journal of Pharmacology, 3: 58-62. ([[http://medwelljournals.com/abstract/?doi=rjpharm.2009.58.62]])
-  * **Sharma A. et al. (2010) **- //FTIR, Ramanova spektroskopia// - "Identification of medicinally active ingredients in ultradiluted Digitalis purpurea. FTIR and Raman spectroscopic studies." Medicinal Chemistry Research, vol. 19, no. 7, pp. 643–651, 2010.([[http://dx.doi.org/10.1007/s00044-009-9219-3]])
-  * **Marschollek et al. (2010) ** - //UV spektroskopia, skúmanie vonkajších vplyvov na homeopatiká// - "Effects of exposure to physical factors on homeopathic preparations as determined by ultraviolet light spectroscopy". Scientific World J (2010), Vol. 10, pp. 49-81 ([[http://www.ncbi.nlm.nih.gov/pubmed/20062950]])
-  * **Wolf et al. (2011) ** - //UV spektroskopia// - "Homeopathic Preparations of Quartz, Sulfur and Copper Sulfate Assessed by UV-Spectroscopy." Evid Based Complement Alternat Med. 2011;2011:692798. ([[http://www.ncbi.nlm.nih.gov/pubmed/19474239]])
-  * **Sharma A., Purkait B. (2012) **- //Florescenčná spektroskopia, cyklická voltametria//- "Identification of Medicinally Active Ingredient in Ultradiluted Digitalis purpurea: Fluorescence Spectroscopic and Cyclic-Voltammetric Study." Journal of Analytical Methods in Chemistry, vol. 2012, Article ID 109058, 5 pages, 2012. ([[http://dx.doi.org/10.1155/2012/109058]])
-  * **Klein et al. (2012) ** -- //UV spektroskopia// - "Investigating homeo- pathic preparations with light spectroscopy." Int J High Dilution Res 2012; 11: 117.([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/view/584]])
-//__Negatívne nálezy:__//
-  * **Aabel et al. (2001) ** - //1H MR Spektroskopia, T1 relaxačné časy//- "Nuclear magnetic resonance (NMR) studies of homeopathic solutions." Br Homeopath J. 2001 Jan;90(1):14-20. ([[http://www.ncbi.nlm.nih.gov/pubmed/11212083]])
-  * **Anick DJ. (2004) **- //1H MR Spektroskopia//- "High sensitivity 1H-NMR spectroscopy of homeopathic remedies made in water." BMC Complement Altern Med. 2004 Nov 1;4:15. ([[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC534805/]])
-__ IV.F.3.) Elektrónová mikroskopia__
-//dôkaz nanočastíc pôvodnej látky aj pri extrémnych zriedeniach//
-  * **Chikramane et al. (2010) ** - "Extreme homeopathic dilutions retain starting materials: A nanoparticulate perspective". Homeopathy (2010), Vol. 99(4), pp. 231-242. ([[http://www.ncbi.nlm.nih.gov/pubmed/20970092]])
-  * **Chikramane et al. (2012) **- "Why extreme dilutions reach non-zero asymptotes: a nanoparticulate hypothesis based on froth flotation." Langmuir. 2012 Nov 13;28(45):15864-75. ([[http://www.ncbi.nlm.nih.gov/pubmed/23083226]])
-__ IV.F.4.) Magnetická rezonancia__
-//Homeopatické preparáty vo vysokých riedeniach vykazujú oproti kontrolným roztokom zmeny relaxačných časov.//
-  * **Demangeat et al. (2004) **- "Low-field NMR water proton longitudinal relaxation in ultrahighly diluted aqueous solutions of silica-lactose prepared in glass material for pharmaceutical use". Appl Magn Reson (2004), Vol. 26, pp. 465-481 ([[http://link.springer.com/article/10.1007%2FBF03166577]])
-  * **Demangeat J-L. (2009) ** - "NMR water proton relaxation in unheated and heated ultrahigh aqueous dilutions of histamine: Evidence for an air-dependent supramolecular organization of water." Journal of Molecular Liquids, 144:32-39 ([[http://www.homeopathyeurope.org/media/news/Demangeat_JML_2009.pdf/view]])
-  * **Baumgartner S. et al. (2009) **- "High-field 1H T1 and T2 NMR relaxation time measurements of H2O in homeopathic preparations of quartz, sulfur, and copper sulfate." Naturwissenschaften, vol. 96, pp. 1079–1089, 2009. ([[http://www.springerlink.com/content/044012g3574214m1/]])
-  * **Demangeat, J.L. (2010) ** - "NMR relaxation evidence for solute-induced nanosized superstructures in ultramolecular aqueous dilutions of silica-lactose" J Molecular Liquids (2010), Vol. 155 ([[http://dx.doi.org/10.1016/j.molliq.2010.05.010]])
-  * **Demangeat (2013) ** -- "Nanosized solvent superstructures in ultramolecular aqueous dilutions: twenty years' research using water proton NMR relaxation."" Homeopathy. 2013 Apr;102(2):87-105. ([[http://www.ncbi.nlm.nih.gov/pubmed/23622259]])
-//__Negatívne nálezy:__//
-  * **Aabel et al. (2001) **- //T1 relaxačné časy, 1H MR Spektroskopia//- "Nuclear magnetic resonance (NMR) studies of homeopathic solutions." Br Homeopath J. 2001 Jan;90(1):14-20. ([[http://www.ncbi.nlm.nih.gov/pubmed/11212083]])
-  * **Milgrom et al. (2001) ** - //T2 relaxačné časy// - //nie je rozdiel v relaxačných časoch medzi zriedenou a potencovanou substanciou//- "On the investigation of homeopathic potencies using low resolution NMR T2 relaxation times." Brit Hom J (2001), Vol. 90(1), pp. 5-13 ([[http://www.ncbi.nlm.nih.gov/pubmed/11212090]])
-__ IV.F.5.) Kalorimetria, elektrická vodivosť, potenciometria__
-//Vysokozriedené (a potencované) substancie za Avogadrov limit sa líšia svojimi fyzikálno-chemickými vlastnosťami oproti samotnému rozpúšťadlu.//
-  * **Elia V, Niccoli M (1999) ** - "Thermodynamics of extremely diluted aqueous solutions." Annals of the New York Academy of Sciences, 879:241–248 ([[http://www.ncbi.nlm.nih.gov/pubmed/10415834]])
-  * **Petrov SI, Epstein OI. (2003) **- "Effect of potentiated solutions on mercury(II) signal in inversion voltammetry." Bull Exp Biol Med. 2003 Jan;135 Suppl 7:99-101. ([[http://dx.doi.org/10.1023/A%3A1024707519510]])
-  * **Elia V, Niccoli M (2004) ** - "New physico-chemical properties of extremely diluted aqueous solutions." Journal of Thermal Analysis and Calorimetry, 75: 815–836 ([[http://dx.doi.org/10.1023/B:JTAN.0000042179.07858.c8]])
-  * **Elia et al. (2004) ** - "Permanent physico-chemical properties of extremely diluted aqueous solutions of homeopathic medicines." Homeopathy, Volume 93, Issue 3, Pages 144-150. ([[http://dx.doi.org/10.1016/j.homp.2004.04.004]])
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-__ IV.F.6.) Biokryštalizácia__
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-__ IV.F.7.) Kirlianov efekt__
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