Asimina Triloba.

Paw Paw, or Custard Apple. Anonaceae.

A valuable proving of the late Dr. George Bute on himself, his daughter, and his 15-year-old grandson, from 1864 to 1868; afterwards also proved by E. H. Eisenbrey in 1869-70, in the 1st, 2d and 4th centesimal potencies. Bute used alcoholic extracts from all parts of the plant, ripe and unripe fruit, the green leaves, the bark, and the root. The tree grew in his garden. Dr. Eisenbrey proved the same preparation.

H. W. Taylor communicated in Cincinnati Medical Advance, 1878, a kind of poisoning of five children after eating freely of the fruit. The symptoms are marked t.

Did not care to hold conversation with any one, even his best friends; with aching in lung.
Could not dismiss from his mind what occurred through the day previous; at night. See 37.

Frontal headache, with pain in chest.
Frontal headache, with nausea; t.
Did not rest well the night previous, arose with an unusual headache in left temporal region, involving eye, with an occasional sharp pain over it, increased by a single cough.
On morning of 4th day headache increased; felt uncomfortable all day; stomach felt increased in size; insufficiency of stool; inactivity of bowels and rectum.
Headache, with chill, nausea and belching.

Discharge from nose altered in character from yellow, thick, and at times, especially in morning, hard, flakey, dark grey consistency, at times offensive, to a natural mucous secretion.

Face turns blue, with spasmodic interruption of breathing. See 26.

Corroding sensation in mouth.
Aphthae of children.

Soreness of throat; t.
Fauces red, swollen; tonsils and submaxillary glands enlarged next day; t.

Thirst, with heat; drinks much; desire for ice cold things.

Soon after eating, a loose stool.

Nausea and belching.
Constant belching.
Vomiting.

Stomach felt increased in size, with headache.
Soreness on pressure in region of stomach.

Exercised a good deal through day; experienced a pain in left hypochondrium, and a soreness in region of stomach on pressure.

Soreness in abdomen on pressure; slight pain resembling colic.
Sensation of distension by wind; colic.
Rumbling and pain.

Insufficiency of stool; inactivity of bowels and rectum. See 3.
Diarrhea after eating.
Rumbling pain in abdomen, with desire for stool, which resulted in passage of a soft, pappy, insufficient stool; in evening.
Soreness of anus when wiping it.
Sudden urging to stool, with a sensation as if a stick, thickness of a thumb, passed down rectum; followed by a sudden diarrheical stool, repeating every ten to fifteen minutes, with chilliness, drowsiness and a weak voice.
Diarrhea of yellowish discharges next day; t.
Diarrhea lasting more than four weeks; t.
All children had diarrhea a long time after other symptoms had disappeared; t.

Urine clear as water.
(OBS:) Diuretic.
Urging to urinate, and burning when urinating.

Weak voice. See 20.
Quite hoarse in morning.
Hoarseness, requiring much effort to talk, and seeming as though mucous membrane was thickened and organs slow to respond to effort of speech.
Throat not very sore, not so much so as hoarseness seemed to indicate; slight cough, which is dry.

Talking difficult.
Cramp in chest, lasting three hours, with blueness of face.

A single cough increased pain over eye.
A slight, dry cough.

Dull, aching pain in upper left lung; headache continuing.

Lower end of sternum sore on pressure.

Chill over whole back.
All children had scarlet eruption on neck and upper limbs; t.

Pain in left shoulder, seeming to involve pectoral muscles.

Sharp pain in left hip joint, lasting about half an hour, 11 1/2 A. M., returned half-past 1 P. M.; in evening other pains in joint more mild than former, lasting but a short time.
Eruption in front, below knee, like nettles; itching when uncovering.
Carbuncle on anterior aspect of left thigh; suppuration lasting two weeks; t.

Fever, heat with sleepiness. See 40.
Did not rest well night previous, kept turning and moving all night; could not dismiss from his mind what had occurred through day.
Got up feeling unrefreshed; headache no amel.; quite hoarse; pain in left shoulder. See 32.
Drowsiness and sleeplessness alternating.

Morning: headache agg.; hard discharge from nose; hoarseness; languid and pale.
At 11.30 A. M. and 1.30 P. M.: pain in left hip joint.
Evening: diarrheic stool; pain in left hip joint slight.

Uncovering knee: itching agg.
Open air: exercise in open air is followed by relief of headache.

Chill. See 3 and 31.
Chilliness. See 20.
Heat with thirst.
Fever heat: with desire for something icy cold; with drowsiness; with much thirst.
Chill over back.

Aching in chest more on left than on right side.
Left: headache temporal region; pain in hypochondrium; pain in upper lung; pain in shoulder; pain in hip joint; carbuncle on thigh.
Left to right: eruptions in provers.

As of a stick in rectum.
Sharp pain: over left eye; in left hip joint.
Corroding: in mouth.
Soreness: in throat; in stomach; in abdomen; of anus.
Dull aching: in upper left lung.
Cramp: in chest.
Undefined pain: over eye; in chest; in left hypochondrium; in left shoulder.

Pressure: soreness in epigastrium and abdomen; lower end of sternum sore.
Wiping: anus sore.

Itching red pimples.
Pustules like smallpox, with a red halo, itching, and after scratching forming thick crusts, lasting from six to eight weeks; t.
Itching when undressing in the evening.
Abscesses ripening.
Eruption first on left then on right side.
Nettlerash.
At 10 P. M.: violent fever; had vomited, and was covered with a bright scarlet eruption; pulse 130, full and steady; temperature 105; t.
General desquamation followed; t.

Collateral relations: the Anonaceae, of which the Asim. tr. is the only one proved, although a very important family.
Compare: Illic. anis. (colic); Liriodendron.
Skin of fruit and seeds are fetid, somewhat similar to Stramon.