Chininum Arsenicosum.

Arseniate of Quinine. 2C20 H24 N2O2. As H3. 4H2O.

Until proved by the Philadelphia Clinical Society, at the instigation of Dr. William H. Bigler, who cured with it a case of scrofulous ophthalmia, the only proving we had was the short one by Dr. Muhr, contained in Allen's Encyclopaedia, vol. 3, p. 214, here designated No. 6.

The provers of the Clinical Society are:

1. Dr. W. B. Trites, 2d dec. trit.;
2. Mr. J. J. Sturges, 1st dec. trit.;
3. Mr. E. W. Le Roy, 6th dec. trit. (both under supervision of Dr. C. Mohr);
4. Dr. C. B. Knerr, 30th cent.; and
5. Mr. Walter K. Furness (under supervision of Dr. Knerr) 2d dec. trit.

- Intermittent hemicrania, Altschul, Rck. Kl. Erf., vol. 5, p. 82; Headache, D. F. and J. C. Moore, N. E. Med. Gaz., 1869, vol. 4, p. 446; Occipito-cervico intercostal neuralgia, Payr, Hom. Klinik, 1869, p. 19; Rheumatic headache, H. G. Bojanus, Raue's Rec., 1874, p. 257; Scrofulous ophthalmia and keratitis superficialis, Wm. H. Bigler (unpublished); Malignant angina in scarlatina, Kafka's Therapie, vol. 1, p. 433; Diphtheritis, numerous cases, Findeisen, A. H. Z., vol. 87, p. 113 and 196; Diphtheria, A. Neuschaefer, A. H. Z., vol. 78, 1869; Intermitting diarrhea, Kafka, Rck. Kl. Erf., vol. 5, p. 410; Suffocative attacks in tuberculosis, Kafka, Rck. Kl. Erf., vol. 5, p. 797; Epileptiform spasms, Payr, Hom. Klinik, 1869, p. 2; Intermittent fever, S. R. Geiser, Cin. Med. Adv., vol. 4, p. 79.

Depressed in spirit, with dullness of mind [No. 3].
Listless after previous fever; no desire to do anything [No. 2].
Desire to sit or lie in one place and not be disturbed [No. 2].
Mental dullness, with inclination to vomit [No. 3].
Anxiety and nightly delirium. ~ Diphtheria.
The chilly waves are brought on by thinking of them [No. 2].
Anxiety, with dyspnea. ~ Tuberculosis.
Greatest anxiety, with unquenchable thirst; must sit up bent forward, if possible at open window. ~ Tuberculosis.
Greatest anxiety, with unquenchable thirst; must sit up bent forward, if possible at open window. ~ Tuberculosis.
Child sits up in bed lamenting. ~ Keratitis.
He believes he cannot long endure such utter prostration. ~ Epilepsy.
Irritable mood precedes headache, which is agg. by mental and bodily exercise. ~ Hemicrania.
In consequence of fright, left sided hemicrania.

Confused feeling in head. ~ Diphtheria.

Severe, darting, tortuous pains running up into head and preventing sleep.
Without previous aura he feels it rushing like lightning through brain and down right side of neck into arm, which is distorted and wrenched so as to crack audibly; the facial muscles are convulsively drawn, sight and speech cease, consciousness leaves, and he falls to the ground; the attack is followed by cold sweat, loud eructations and a feeling of utter prostration. ~ Epileptiform spasms.
Confused headache [No. 1].
Frontal and occipital headache [No. 1].
Headache affecting occipital protuberance [No. 1].
Dull headache in frontal region, not relieved by eating [No. 3].
Neuralgic pain in right temple and above eye, lasting several days, with inclination to move skin over aching place with his hand [No. 5].
Tearing, boring pain in left side of head, affecting eye, with flickering, pain and lachrymation; ringing in ears, nausea and vomiting during attack, which regularly appears at midnight; is subject to furuncles and abscesses which relieve head.

Burning pain in left occipital protuberance, extending down nape of neck, along shoulder blade and over left half of thorax, producing orthopnea; attack commences with stretching and yawning and a shaking chill, generally in morning, and lasts until after midnight.
Bruised feeling all over head after fever and sleep [No. 2].
Neuralgic pain about head, particularly in temples; agg. in left side; amel. by rubbing aching spots [No. 4].
Slight painful pressure in forehead and temples [No. 6].
Slight sudden throbbing of temporal arteries after 1 P. M.

Intense photophobia and spasms of orbicularis muscles, gushing hot tears, large ulcers attacking each eye, aggravation from midnight until 3 A. M., during which time the child sat up in bed lamenting. ~ Keratitis.
Scrofulous ophthalmia; agg. after 1 A. M.
Flickering before left eye, with pain and lachrymation. ~ Hemicrania.

Ringing in ears. ~ Hemicrania.

Watery discharge from nose [No. 2].
Constant running of profuse limpid and watery discharge [No. 2].
Yellow discharge from nose [No. 2].
Left nostril fills up when lying on that side [No. 2].
Nostrils stop up, particularly left, on lying down, preventing breathing through nose [No. 2].
Nose clearer when prover is in an erect posture and out of doors [No. 2].
Sneezing, agg. sore throat [No. 2].
Profuse discharge from both nostrils [No. 2].
Nose stopped up with purulent and bloody substance. ~ Diphtheria.
Corners of nose excoriated. ~ Diphtheria.

Face pale, sallow and bloated. ~ Intermittent fever.

Swelling of submaxillary and parotid glands. ~ Diphtheria.
Blueness of lips. ~ Tuberculosis.

Sweetish taste after clearing throat and coughing [No. 2].
Yellow slimy coating on tongue, with bitter taste [No. 3].
Soreness and redness of tip of tongue [No. 4].
Metallic bitter taste in mouth [No. 6].
Tongue coated thick and brown. ~ Diphtheria.

Burning canker spot inside of left upper lip [No. 4].
Fetor oris. ~ Diphtheritis. ~ Scarlatina.

Post-nasal catarrh; agg. on left side [No. 2].
Diphtheria, diffused blackish exudation, hoarseness, great prostration, confusion in head, nightly delirium, difficult swallowing, fetid stench from mouth, dry tongue, dry skin, pulse 130, fever assuming a putrid type [No. 3].
Constant hacking and clearing of throat [No. 2].
Throat feels sore and inflamed, with a good deal of cough [No. 2].
Throat feels raw and sore; agg. by coughing and sneezing [No. 2].
Malignant angina during scarlatina, with paleness of skin, quick exhaustion and rapid destruction of mucous membrane of fauces.
Diphtheria: fetor oris, swelling of submaxillary glands, frequently also of parotids, violent fever and great prostration.
Diphtheria: strong fetor oris; submaxillary glands swollen and painful; breathing through mouth because nose is stopped up with purulent and bloody substance; corners of nose excoriated; tongue coated thick and brown, both tonsils covered with a grey exudation, on right tonsil a bloody ulcer with uneven edges which corresponded to size of a membrane just retched out; lower half of uvula gangrenous, upper half covered with exudation; posterior wall of fauces completely covered with exudation; swallowing of liquids very difficult; great weakness; sleeplessness; pulse small, very frequent.

No appetite for breakfast after fever in the night [No. 2].
No thirst with the fever [No. 2].
Thirst which cannot be appeared; during attacks of suffocation. ~ Tuberculosis.

Eggs and fish cause painless diarrhea at once. ~ Rheumatic headache.
She does not like cold water. ~ Rheumatic headache.
Water tastes bitter, or has a disagreeable flavor like the water found in cars [No. 2].

Inclination to vomit, with mental dullness [No. 3].
Sudden inclination to vomit at 2 P. M., lasting only a few minutes [No. 3].
Regurgitation of food [No. 4].
Eructations. ~ Epilepsy.
Nausea and vomiting, followed by sleep. ~ Hemicrania.

Sensation from stomach through entire intestinal canal as if diarrhea would set in [No. 4].
Burning, sore feeling in stomach; agg. on motion, particularly going up-stairs [No. 4].
Uncomfortable feeling in stomach is amel. by expanding chest [No. 4].
Burning in stomach [No. 4].

Left hypochondriac region enlarged. ~ Intermittent fever.

Abdomen bloated. ~ Intermittent fever.
Sore pain in a small spot, which could be covered with tip of a finger below and to right of umbilicus, coming and going, but continuing all day [No. 1].
Very severe colic [No. 6].
Pressure in solar plexus, as if he had eaten tough meat or hard nuts, extending towards back where it changes to a pinching sensation, spine painfully sensitive to touch at this point [No. 6].

Diarrhea from malarious poisoning; stools thin, watery, undigested, offensive, dark or light brown, sometimes with a meal-like sediment.
From ten to fifteen painless, watery, very offensive stools from 6 to 10 A. M., with burning in anus after each passage; slightly emaciated, pale and weak.
Fetid diarrhea with pains in bowels. ~ Intermittent fever.

Spasmodic retention of urine; amel. by application of hot cloths to chest, which, however, is followed by syncope. ~ Occipito-intercostal neuralgia.

Hoarseness. ~ Diphtheria.
Aching in bronchial region; agg. left side [No. 4].
Seemed to prevent diphtheritic membrane from spreading to larynx. ~ Malignant scarlatina.

Respiration very free as if thorax was hollow [No. 6].
Blueness of lips, hands and nails, with attacks of suffocation, which begin in morning and last until noon. ~ Tuberculosis.
Must sit bent forward and if possible at an open window during attack of suffocation; agg. by any other position.
Dyspnea with anxiety. ~ Tuberculosis.
Every forenoon at 9 o'clock attacks of suffocating spells.

Coughing agg. sore throat [No. 2].
Cough with but little expectoration [No. 2].
Slight cough at long intervals, seems to come from full feeling in chest [No. 2].

Senile subacute catarrh with periodical fever, generally agg. at night.
Peculiar colicky pain in lower part of left lung felt like a pain from flatulence, comes and quickly passes away, often repeated [No. 1].
Sharp stitch in lower part of right chest in front; agg. when inspiring, causing him to cry out [No. 1].
Desire to inflate lungs to their fullest extent to relieve uncomfortable feeling in stomach while riding in open air on a raw, cold day [No. 4].
The chest feels hollow and respiration freer [No. 4].
Limbs icy cold; cold clammy sweat all over; greatest anxiety and unquenchable thirst; must sit up, bent forward if possible, at open window. ~ Tuberculosis.

Angina pectoris, with dropsical symptoms, venous hyperemia and cyanosis.
Trembling of heart, with rumbling noise, unable to distinguish pulsations, lasting one hour [No. 6].
Palpitation; noticed on leaning against back [No. 6].
Sensation as if heart had stopped [No. 6].
No perception of beating of heart [No. 6].
Beat of heart and pulse irregular, numbering 200 per minute [No. 6].
Pulse cannot be felt on left side [No. 6].
Beat of heart becomes regular towards noon [No. 6].
Pulse in radial and temporal arteries 200 [No. 6].
Pulse small, very frequent. ~ Diphtheria.
Pulse 130. ~ Diphtheria.
Pulse 98, full and strong during fever [No. 2].

Paralysis of respiratory muscles on left side. ~ Intercostal neuralgia.
Violent neuralgic pain in left mammary region, as though that part was torn with red hot tongs. ~ Intercostal neuralgia.
Aching in intercostal muscles, right side, in locality of sixth and seventh ribs on making inspiration [No. 4].

Back feels weak as after taking a long journey [No. 2].
Pain in muscles between left shoulder and neck, as if sprained, on rising from sleep at 4 P. M. [No. 4].

Painful weariness in shoulder and elbow joints [No. 6].
Aching in biceps of left arm [No. 1].
Acute fugitive pain in left olecranon process [No. 1].
Pain in flexors of left forearm on radial side near elbow [No. 1].
Palms of hands hot and dry [No. 1].
Sore, aching fugitive pains in first phalanx of left thumb, the same, but in a less degree, in right [No. 1].
Blueness of hands and nails. ~ Tuberculosis.

Weariness of lower extremities.
Gooseflesh on lower extremities, with chilly feeling [No. 2].
Sore, aching fugitive pain in left leg near knee [No. 1].
Aching, sore pain in anterior lower two-thirds of left tibia [No. 1].
Itching on internal malleolus of right foot at 2 A. M.; on investigation discovered eruption of bright red pimples [No. 4].
Increased tenderness of corn on left little toe; had to remove shoe to ease pain [No. 4].

Limbs icy cold. ~ Tuberculosis.

Desire to sit or lie in one place.
Desire to move skin over aching place in temple with his hand.
Lying: on left side, nostril fills up.
Sitting: bent forward amel. anxiety and suffocation.
Leaning against back: palpitation noticeable.
Erect posture: nose clearer.
Expanding chest: amel. uncomfortable feeling in stomach.
Motion: and going up-stairs agg. burning soreness in stomach; agg. intercostal neuralgia.
Bodily exercise: headache.
Riding in open air: desire to expand lungs to relieve uncomfortable feeling in stomach.
Sneezing: agg. sore throat; and coughing agg. rawness in throat.

Great prostration. ~ Diphtheria.
Lassitude and fatigue [No. 4].
Feels as when suffering from partially developed malaria [No. 1].
Felt sore and ached all over [No. 1].
Felt like one having taken a long journey [No. 2].
Great prostration, followed by a deep sleep after an attack of dyspnea. ~ Tuberculosis.
Epilepsy; after attack cold perspiration, eructations, and a feeling of such utter prostration that patient believes he cannot endure it long.

Goes to sleep after tea and sleeps heavily all night [No. 4].
Deep sleep after suffocative attacks. ~ Tuberculosis.
Awakes from sleep exhausted and bathed in sweat after an attack of dyspnea. ~ Tuberculosis.
Restless until 3 A. M., constantly changing position, particularly as soon as pillow becomes warm [No. 6].
Sleep frequently interrupted [No. 6].
Sleeplessness. ~ Diphtheria.

Nightly: delirium in diphtheria.
At night: senile subacute catarrh agg.; sleeps heavily; is more feverish.
From midnight until 3 A. M.: ophthalmia agg.
From morning until after midnight: burning pain in head with chills.
At 2 A. M.: itching eruption on internal malleolus of right foot.
Until 3 A. M.: restless.
At 4 A. M.: sprained feeling in muscles of back.
From morning to noon: suffocation, with blueness of lips, hands and nails.
In morning: broken-up feeling after fever, no appetite for breakfast.
From 6 to 10 A. M.: diarrhea.
At 9 A. M.: suffocating spells.
Towards noon: beat of heart becomes regular.
Forenoon: chill at irregular hours.
Towards midnight: fever following chilliness, pulse 90.
After 1 P. M.: throbbing of temporal arteries.
At 2 P. M.: sudden inclination to vomit.
After 8.30 P. M.: chilliness with goose-flesh.

Hot cloths to chest: amel. retention of urine but cause syncope.
Warmth of pillow: agg. restlessness.
Open window: sits there to amel. anxiety and suffocation.
On a raw, cold day, while riding, desire to expand lungs to relieve uncomfortable feeling in stomach.
Damp weather: is sensitive to it, and feels chilly. ~ Rheumatic headache.
Cool part of bed: agg. chilliness.
Inclination to throw off covers and open windows: with fever towards midnight.

Chilly feeling like cold waves after 8 1/2 P. M. in bed, with gooseflesh all over body, but particularly on legs [No. 2].
Chilliness coming in waves, with restlessness; agg. by moving hands and feet to a cool part of bed, also by thinking of it [No. 2].
Chill always in forenoon, not at a regular hour, however; sometimes once every day, again every other day; sometimes paroxysms would close with perspiration, sometimes without; before the attack headache, yawning and stretching. ~ Intermittent fever.
After chilliness, feverish towards midnight, pulse 98, full and strong, with inclination to throw off covers and open windows, no sweat [No. 2].
Feverish all the time, but more so at night [No. 2].
No sweat after fever, but weak, broken-up feeling in morning and no appetite for breakfast [No. 2].
Violent fever with great prostration. ~ Diphtheria. ~ Malignant scarlatina.

Periodically: furuncles and abscesses. ~ Hemicrania.
Like cold waves: chilliness in evening.
At long intervals: slight cough from full feeling in chest.
Coming and going quickly: peculiar colicky pain in lower part of left lung, often repeated.
Coming and going, all day: sore pain in spot below and to right of umbilicus.
Lasting a few minutes: inclination to vomit.
Lasting one hour: tremor of heart.
Every day or every other day: chill; attacks of suffocation.
Lasting several days: neuralgia in head.

Left: hemicrania; boring in side of head, affecting eye; burning in occipital protuberance, down nape of neck, along shoulder blade and over half of thorax; neuralgia about head; flickering before eye; nostril fills up when lying on side; canker spot inside upper lip; post-nasal catarrh agg.; hypochondriac region enlarged; aching in bronchial region; peculiar colicky pain in lower part of lung; pulse cannot be felt; paralysis of respiratory muscles; neuralgia in mammary region; pain as if sprained between shoulder and neck; aching in biceps; acute pain in olecranon process; pain in flexors of forearm; pains in thumb; pain in leg near knee; pain in anterior lower two-thirds of tibia; tender corn on little toe.
Right: rushing like lightning through brain and down side of neck into arm; neuralgia in temple and above eye; diphtheritic ulcer on tonsil; sore pain in small spot to right of umbilicus; sharp stitch in lower part of chest, in front; aching in intercostal muscles, locality of sixth and seventh ribs; pains in thumb; itching eruption on internal malleolus of foot.

As if diarrhea would set in; as if heart had stopped; as if torn with red hot tongs in left mammary region; as after a long journey, weakness in back; as if he had eaten tough meat or hard nuts, in solar plexus; as when suffering from partially developed malaria; as if thorax was hollow.
Pains: in flexors of left forearm.
Acute pain: in left olecranon process.
Neuralgic pain: in right temple and above eyes; about head, particularly in temples; in left mammary region.
Stitch: in lower right chest.
Darting: running up into head.
Tearing: in left side of head and eye.
Boring: in left side of head and eye.
Burning: in left occipital protuberance to nape of neck, along shoulder blade and over left half of thorax; canker spot in upper lip; in stomach; in anus.
Colicky pain: in abdomen; in lower part of left lung.
Raw feeling: in throat.
Sore pain: in a small spot below and to right of umbilicus.
Sprained pain: in muscles of back between shoulder and neck.
Pinching: back, in region of solar plexus.
Pressure: in forehead and temples; in solar plexus.
Tenderness: of corn on left little toe.
Aching: in bronchial region; in intercostal muscles right side; in biceps; in phalanges of thumbs; in left leg near knee; in anterior lower left tibia; all over.
Dull pain: in frontal region.
Bruised feeling: all over head.
Sore feeling: in throat; in stomach; all over; tip of tongue.
Broken-up feeling: in morning after fever.
Lightning-like sensation runs through brain and down right side of neck into arm.
Tortuous pains: run up into head.
Hollow feeling: in chest.
Uncomfortable feeling: in stomach.
Weariness, painful: in shoulder and elbow joints; in lower extremities.
Throbbing: of temporal arteries.
Chilly feeling: with goose-flesh all over body.
Itching: on internal right malleolus.

Dropsical symptoms, venous hyperemia and cyanosis.

Touch: spine sensitive to.
Rubbing: amel. aching spots in head.
Pressure of shoe: agg. aching of corn.

Recommended in plague by Lorbacher.
Dry skin. ~ Diphtheria.
Gooseflesh over whole body, particularly lower extremities [No. 2].
Pallor of skin, with rapid exhaustion. ~ Scarlatina.
Cold, clammy sweat all over. ~ Tuberculosis.
Cold perspiration after attacks. ~ Epilepsy.
Periodical furuncles and abscesses, which relieve the head. ~ Hemicrania.

Albert S., aet. 4; had chills for two weeks; intermittent fever.
A stout girl, aet. 10; diphtheria.
A young lady of slender build, aet. 20; diphtheria.
A tuberculous woman, aet. 30; suffocative attacks.
Strong man of sanguine temperament; intermittent hemicrania of three years' standing.
A man; epileptiform spasms of nine years' standing, caused by masturbation and use of spirituous drinks.
Woman, aet. 50; diarrhea.
Lady, aet. 58; hydrogenoid constitution; rheumatic headache.

Compare: Apis (diphtheria), Arsen. (neuralgias, diarrhea, tuberculosis), Cinchon. (diarrhea, suffocative attacks in tuberculosis).